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DOI: 10.1055/a-2645-0537
Mild and Efficient Synthesis of Sulfonyl Fluorides from Sulfonamides Enabled by Diethylaminosulfur Trifluoride
We thank Kiel University for financial support.
Abstract
A simple method for the synthesis of sulfonyl fluorides from secondary sulfonamides is described. The commercially available fluorinating agent diethylaminosulfur trifluoride (DAST) is used to efficiently transform structurally diverse secondary sulfonamides in high yields. We further demonstrate the utility of this method for the generation of sulfonamide compound libraries from a given sulfonamide starting material as well as the scalability of our method to gram scale reactions.
Publication History
Received: 03 June 2025
Accepted after revision: 27 June 2025
Accepted Manuscript online:
27 June 2025
Article published online:
29 July 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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